The mysql.user table in MySQL 5.6 has a password_expired column. The mysql.user table in MySQL 5.5 does not. This means that an account with an expired password in MySQL 5.6 will work normally in MySQL 5.5.

InnoDB search indexes (with a type of FULLTEXT), introduced in MySQL 5.6.4, are not compatible with earlier versions of MySQL, including earlier releases in the 5.6 series. Drop such indexes before performing a downgrade.

InnoDB small page sizes specified by the innodb_page_size configuration option, introduced in MySQL 5.6.4, are not compatible with earlier versions of MySQL, including earlier releases in the 5.6 series. Dump all InnoDB tables in instances that use a smaller InnoDB page size, drop the tables, and re-create and reload them after the downgrade.

As of MySQL 5.6, the relay-log.info file contains a line count and a replication delay value, so the file format differs from that in older versions. See Section 16.2.2.2, “Slave Status Logs”. If you downgrade a slave server to a version older than MySQL 5.6, the older server will not read the file correctly. To address this, modify the file in a text editor to delete the initial line containing the number of lines.

Beginning with MySQL 5.6.6, the MySQL Server employs Version 2 binary log events when writing the binary log. Binary logs written using Version 2 log events cannot by read by earlier versions of MySQL Server. To generate a binary log that is written using Version 1 log events readable by older servers, start the MySQL 5.6.6 or later server using --log-bin-use-v1-row-events=1, which forces the server to employ Version 1 events when writing the binary log.