If you have many MyISAM tables in the same
database directory, open, close, and create operations are
slow. If you execute SELECT
statements on many different tables, there is a little
overhead when the table cache is full, because for every table
that has to be opened, another must be closed. You can reduce
this overhead by increasing the number of entries permitted in
the table cache.

User Comments
Here is more information on table cache resizing, see "table_cache": http://www.mysql.com/doc/en/Server_system_variables.html
you can set the table_cache value in the my.cnf file by
set-variable = table_cache=8
Or
If you have the SUPER privilege then, use
set GLOBAL table_cache=8;
since the Variable 'table_cache' is a GLOBAL variable it should be set with SET GLOBAL
-Kumar@guyfromchennai.com
Filesystem directory-lookup issues are moot on filesystems with efficient directory indexes (such as XFS).
You may still need to tune table_cache though.
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